Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats

نویسندگان

  • Ryusuke Saito
  • Takeshi Muneta
  • Nobutake Ozeki
  • Yusuke Nakagawa
  • Mio Udo
  • Katsuaki Yanagisawa
  • Kunikazu Tsuji
  • Makoto Tomita
  • Hideyuki Koga
  • Ichiro Sekiya
چکیده

BACKGROUND It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis. METHODS Rats were forced to run 30 km over 6 weeks and the dropout rate was examined. One week after 0.1 mg mono-iodoacetate was injected into the right knee, rats were forced to run either 15 km or not run at all over 3 weeks, after which knee cartilage was evaluated. Synovium at the infrapatellar fat pad was also examined histologically. RESULTS Even though all 12 rats run up to 15 km, only 6 rats completed 30 km of running. Macroscopically, 0.1 mg mono-iodoacetate induced erosion at the tibial cartilage irrespective of 15 km of running. Histologically, 0.1 mg mono-iodoacetate induced loss of cartilage matrix in the tibial cartilage, and an additional 15 km of strenuous running significantly exacerbated the loss. Synovitis caused by mono-iodoacetate improved after running. CONCLUSIONS Only 50% of rats completed 30 km of running because of foot problems. Strenuous running further exacerbated tibial cartilage erosion but did not influence synovitis induced by mono-iodoacetate.

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عنوان ژورنال:

دوره 18  شماره 

صفحات  -

تاریخ انتشار 2017